Description

Research Scientist, Antibody Discovery and Research

Job #25-06A

Mapp Biopharmaceutical, Inc. "Mapp" is a San Diego based, innovative biopharmaceutical company focused on addressing unmet medical needs through the development of life-saving monoclonal antibody treatment options to combat a variety of neglected and tropical infectious diseases, and in support of biodefense programs.

The Early Research and Development Group (ERDG) and the Advanced Research and Development Group (ARDG) at Mapp Biopharmaceutical are responsible for the execution of high quality Research and Development activities to ensure the achievement of a robust portfolio through CMC, Nonclinical, Regulatory, Project Management, and Clinical activities consistent with Mapp's product development objectives.

The Research Scientist works in the antibody discovery group which is responsible for isolating novel antibodies that may be used in future drug products. This includes creating and producing the antigens necessary to isolate these antibodies and assessing the antibodies for their potential as therapeutics. The Research Scientist, Antibody Discovery and Research will provide overall support for our projects including design, execution, supervision, analysis and interpretation of results.

Basic Qualifications

• PhD or equivalent in biology, molecular biology, biochemistry, virology, and/or related field
• Post doc experience or other appropriate scientific experience
• Author on scientific publications in respected peer reviewed journals
• Demonstrated excellence in the following competency areas:
  • Protein expression in bacterial, mammalian and insect cell systems
  • Protein purification, including experience with automated HPLC and FPLC systems, fluency in GE Unicorn FPLC software
  • Flow cytometry and single B-cell sorting techniques
• Experience in leading scientific personnel to execute against program deliverables
• Experience with ForteBio Octet technology and isothermal titration calorimetry
• Hands-on experience operating IncuCyte and similar high-content live-cell imaging systems
• Experience effectively troubleshooting experimental strategies in the laboratory

Preferred Qualifications

• Experience with primer design and RT-PCR particularly for monoclonal antibody isolation and cloning from single B-cells
• Experience expressing and purifying viral proteins
• Experience with reverse genetics and pseudo typed viral vector systems.
• Command of in-silico workflows for antibody and protein engineering and optimization
• Development of functional cell based assays/immunoassays to assess mechanism of action and potency of new antibody candidates (e.g. reporter assay, internalization assay, neutralization assay, shedding assay ADCC-assay, ADCP-assay, multi-color flow etc.)
• Generation of stable cell lines using lentivirus transduction and validation of those cell lines via flowcytometry and western blot

Responsibilities

• Optimizes and designs expression constructs for protein stability, solubility and expression levels
• Designs and optimizes strategies to generate and purify proteins of interest for subsequent in vitro and in vivo applications
• Designs and develops novel in vitro assays to assess antibodies for binding and activity
• Supervises research scientists at various levels as needed
• Reviews and synthesize new research findings regularly
• Maintains detailed records of all experiments performed
• Presents and communicates effectively experimental results to the group

Mapp offers a competitive compensation and benefits package in addition to this exciting and challenging job. Mapp's anticipated pay scale for this position is $80,000 to $130,000 per year plus any applicable bonuses. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the candidate's level of education, and type and length of experience within the job and/or within the industry. Medical, dental, and vision insurance benefits are available to eligible employees and their families. Mapp also provides basic life insurance, short and long term disability, and a 401K plan that includes Company contributions to eligible employees. Full time employees will be provided 7 days of sick time, 14 paid holidays, and will also accrue 18 days of vacation throughout the calendar year.

This position is an on-site position located in Mapp's new state-of-the-art San Diego facility. Willingness to Travel (Domestic Travel = Approximately 2x per year + International Travel = Approximately 1x per year) will be required for this position.

Mapp wants you to join their team and invites you to apply by submitting your information through the Mapp Biopharmaceutical, Inc. Job Openings website page. This job will remain open for twenty (20) days after being posted on Mapp's Job Openings website page.

No Solicitors, agents or placement agencies please. Mapp utilizes E-Verify.

Mapp is an equal opportunity employer and employment decisions are not based on any protected status. Mapp uses a wide variety of advertising and outreach to find qualified applicants for employment.

Mapp is an Equal Opportunity Employer/Veterans/Disabled.

For more information, or to apply now, you must go to the website below. Please DO NOT email your resume to us as we only accept applications through our website.

https://mappbio.applicantpro.com/jobs/3852651-960382.html